In the past, proteoglycans were too expensive and rarely distributed to the market.
However, since highly effective extraction method from salmon nasal cartilage was
developed, proteoglycans has been attracting great deal of attention as a new
ingredient, especially from health food and cosmetics industries. Therefore, the
number of researches and clinical studies on proteoglycan is growing.
Sashinami H, et al. Salmon cartilage proteoglycan modulates cytokine
responses to Escherichia coli in mouse macrophages.Biochem Biophys
Res Commun. 2006 Dec 29;351(4):1005-10.
Goto M, et al. Anti-aging effects of high molecular weight proteoglycan
from salmon nasal cartilage in hairless mice.Int J Mol Med.
Takahashi T, et al. Ingestion of salmon nasal cartilage-derived proteoglycan
improves skin condition: A randomized, double-blind, controlled
Endocr Metab Agents Med Chem.2015 Aug 1;15(2):160-7.
Najima M, et al. Usefulness of the supplement containing proteoglycan for
Japanese healthy people feeling knee’s discomfort.Shinryo to
Kuriyama Y, Yoshida Y. Efficacy of dietary supplement contained proteoglycan
extracted from salmon nasal cartilage on knee uncomfortableness in healthy
volunteers.Jpn Pharmacol Ther.2017;45:1795-808.
Tomonaga A, et al. Evaluation of the effect of salmon nasal proteoglycan on
biomarkers for cartilage metabolism in individuals with knee joint
randomized doubleblind placebo-controlled clinical study.Exp Ther