Clinical study results
EVIDENCE SHOWING EFFECTS ON THE KNEE AND SKIN
LINISE focuses on not only manufacturing but also studying products to know how our products work in the human body and how much benefits those can bring to us. Our research never ends and will reveal more about unknown potency of proteoglycan and salmon.
In the clinical study involving 60 healthy individuals with uncomfortable feeling in their knees, effects of a salmon nasal cartilage extract (containing 40% undenatured type II collagen and 30% undenatured proteoglycan, 50 mg/day) on the knees were evaluated and compared with those of placebo and glucosamine hydrochloride. As the results of WOMAC and VAS evaluation, the salmon nasal cartilage extract showed the efficacy against knee joint pain. (Right figure: Variation and transition of the VAS score for left knee pain in using stairsteps.)
Kuriyama Y, et al. Effects of taking salmon nasal cartilage extract (containing undenatured type II collagen and undenatured proteoglycan) on knee joint pain. J New Rem & Clin. 2016;65(11).
The data from our previous study was re-analyzed with a new approach, which focused on the unilateral knee having more pain than the contralateral knee. In the salmon nasal cartilage extract (SNCE) group, as compared with the placebo group, the VAS pain score (in a resting state and in going up and down stairs) at Week 6 was significantly decreased. The glucosamine group did not show significant improvement in the VAS pain score at Week 6.
This re-analysis clearly demonstrated that the 6-week intake of salmon nasal cartilage extract provides the benefit of reducing knee pain.
Time course of VAS pain score
In a resting state
SNCE group: 18 participants; daily intake, 50 mg of SCP Complex-LS (trade name in the United States: SCP-II®) containing undenatured type II collagen and undenatured proteoglycan.
Glucosamine group: 18 participants; daily intake, 1,500 mg of glucosamine hydrochloride.
Placebo group: 18 participants; daily intake, 50 mg of lactose.
In going up and down stairs
Kuriyama Y, et al. Effects of Salmon Nasal Cartilage Extract Powder Standardized Undenatured Type II Collagen and Proteoglycan on Knee Pain in Healthy Volunteers—A Single Center Randomized, Double-blind, Placebo-controlled Study—: Re-analysis results focused on the knee with stronger pain. Jpn Pharmacol Ther. 2020;48(11).
Soluble Proteoglycan
In a dermatologist-supervised clinical study†,
The effect diminishing the appearance of wrinkles caused by drying was demonstrated.
†Conducted by the third-party institution according to the Guideline for Evaluation of Anti-wrinkle Products established by Japanese Cosmetic Science Society.
Soluble Proteoglycan produced by Linise (Hokkaido, Japan) was applied around one eye for comparing the appearance of wrinkles with around the other eye.
Participant
17 healthy Japanese females (mean age: 40.3 [36-45] years old)
Study Period
6 weeks
Evaluation Methods
Determining a wrinkle grade by visual and photo evaluations
(The above graph is made using the mean values of 17 subjects: *p<0.05, **p<0.01)
As the results of comparing wrinkles between baseline (BL), 3 weeks later (W3), and 6 weeks later (W6), the wrinkle grading score was decreased at the corner of eye on the proteoglycan-applied side.
The skin-moisture measurement showed an increase in moisture level.
As the result of comparing skin (horny layer) moisture between BL, W3, and W6, all subjects showed an increase in moisture around the eye where Soluble
Proteoglycan was applied.
(The above graph is made using the mean values of 17 subjects: **p<0.01)
The result of questionnaire survey conducted at W6 indicates that many participants felt improvement in their skin condition.
Participant's Comments
- ✓ I can notice the improvement of firmness around the eye.
- ✓ My skin became very moistened, I wanted to keep using the product a little bit longer.
- ✓ Very nice feeling of hydrated skin.
- ✓ Happy with the effect on fine wrinkles.
- ✓ Moistened.
- ✓ I am satisfied by the improvement in skin moisture around the eye.
- ✓ Seemed like the crow's feet were diminished. I felt my skin was hydrated.
- ✓ High moisturizing effect.
- ✓ Seemed like my skin was moistened and became a little plump.
- ✓ Great. The eye is looked clear and winkles are diminished.