In the past, proteoglycans were too expensive and rarely distributed to the market. However, since highly effective extraction method from salmon nasal cartilage was developed, proteoglycans has been attracting great deal of attention as a new ingredient, especially from health food and cosmetics industries. Therefore, the number of researches and clinical studies on proteoglycan is growing.

Sashinami H, et al. Salmon cartilage proteoglycan modulates cytokine responses to Escherichia coli in mouse macrophages.Biochem Biophys Res Commun. 2006 Dec 29;351(4):1005-10. →learn more
Goto M, et al. Anti-aging effects of high molecular weight proteoglycan from salmon nasal cartilage in hairless mice.Int J Mol Med. 2012 May;29(5):761-8. →learn more
Takahashi T, et al. Ingestion of salmon nasal cartilage-derived proteoglycan improves skin condition: A randomized, double-blind, controlled study.Immun Endocr Metab Agents Med Chem.2015 Aug 1;15(2):160-7.
Najima M, et al. Usefulness of the supplement containing proteoglycan for Japanese healthy people feeling knee’s discomfort.Shinryo to Shinyaku (Med Cons New-Remed).2016;53(3):228-36.
Kuriyama Y, Yoshida Y. Efficacy of dietary supplement contained proteoglycan extracted from salmon nasal cartilage on knee uncomfortableness in healthy volunteers.Jpn Pharmacol Ther.2017;45:1795-808.
Tomonaga A, et al. Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized doubleblind placebo-controlled clinical study.Exp Ther Med. 2017 Jul;14(1):115-26. →learn more